pentobarbital will minimize the level or influence of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.Caution is warranted for individuals with renal and hepatic impairment. When the